Neither team are particularly bothered about this competition considering they are both in the hunt for a Premier League title, although Roberto Di Matteo’s side will want to exact some kind of revenge for Sunday’s controversial defeat which saw United win 3-2 against a Chelsea team that finished the game with nine men.
Meanwhile, Tottenham Hotspur travel to Norwich City and Andre Villas-Boas will surely give the likes of Jermain Defoe and Gareth Bale the night off after a hectic recent fixtures schedule, with Brendan Rodgers coming face-to-face with former club Swansea City.
Chelsea v Manchester United 19:45
After an eight game unbeaten run, Chelsea have conceded five goals in their last two matches against Shakhtar and Manchester United which means they go into this match on a hat-trick of defeats.
Indeed, the clean sheets have dried up for the Blues since that 4-0 whipping of Nordsjaelland and John Terry remains banned for this contest, with Branislav Ivanovic and Fernando Torres also suspended after their red cards at the weekend. Even so, Chelsea are the 13/10 favourites (BetVictor free bets) to beat their rivals and reach the League Cup quarter finals.
This will be a chance for the Stamford Bridge faithful to watch Marko Marin who has so far played just twenty minutes against Wolves in the League Cup, while Victor Moses and Oriol Romeu will also get an opportunity as Di Matteo looks to rest first-team players ahead of the weekend match against Swansea and next week’s Champions League clash with Shakhtar.
Sir Alex Ferguson will also wrap his key players in cotton wool, with Robin van Persie and Wayne Rooney likely to watch the match from their respective homes although the likes of Anderson, Danny Welbeck and Javier Hernandez will be on the pitch and the Mexican was on hand to score the winner on Sunday.
The visitors are a 21/10 poke (Betfred) to win at the Bridge for the second time in a week and that man Hernandez looks a big price at 9/1 to score first, while Daniel Sturridge can be backed at 8/1 to break the deadlock.
Norwich City v Tottenham Hotspur 19:45
Tottenham are going along very nicely in the Premier League although it’s worth noting that they haven’t mustered a win in any of their Europa League matches this season and Andre Villas-Boas will play a weakened team at Carrow Road for this match against a Norwich team that seem to be improving after a slow start.
After beating Arsenal ten days ago, the Canaries claimed a point at Villa Park and Chris Hughton is likely to field a relatively strong team for this League Cup last sixteen tie where victory would keep the momentum going ahead of the weekend visit of Stoke City.
Norwich are a 7/2 chance (Boylesports) to beat their London opponents and defensively the east Anglian team look a lot tighter in recent weeks, with Spurs likely to have several changes made to the team that won 2-1 at Southampton on Sunday.
AVB would love to win some silverware in his first season at White Hart Lane although you have to think he won’t take the Capital One Cup too seriously considering they have European obligations and there’s also the small matter of a top four place in the Premier League where they could be tussling with Arsenal.
The bookies offer 9/10 (BetVictor) about the visitors winning this match and we will see Kyle Naughton, Jake Livermore and Gylfi Sigurdsson back in the team, although Emmanuel Adebayor may not be fit enough to take his place in the side.
Liverpool v Swansea City 20:00
Brendan Rodgers was a highly successful manager at the Liberty Stadium before the lure of Anfield proved too irresistible in the summer and there must be times where the Liverpool manager wishes he’d stayed put in south Wales.
It’s been a testing start to the season for the Merseyside team although they played pretty well when drawing 2-2 at Goodison Park on Sunday and this tie represents an excellent chance to book a place in the quarter final of the competition, with Kenny Dalglish having steered the Reds to glory last season.
Liverpool are a 4/7 chance (bet365) to win the game after claiming victory at The Hawthorns in the last round with a very inexperienced team that included Jack Robinson, Daniel Pacheco and Samed Yesil.
The same players will get another opportunity against the Swans who have had a decent enough start to the season and weren’t far away from earning a point at the Etihad Stadium on Saturday although Michael Laudrup might consider rotating his team for this match.
In the last round, City rallied to come from behind and beat Crawley 3-2, with the visitors a 13/2 chance (Betfred) to get one over their old manager and they retain the Rodgers blueprint with an attractive passing style which might make the match a lot closer than the odds suggest.