This fixture last season produced plenty of fireworks, with Manchester United storming into a 3-1 lead only for Everton to score twice in injury-time and earn an unlikely 3-3 draw.
It was also a game where Sir Alex Ferguson omitted Wayne Rooney from the squad, although the former Toffee will almost certainly line up at Goodison Park for a game in which the Scot needs a reaction from his first team after that 6-1 drubbing against Manchester City.
While the Red Devils won 3-0 at Aldershot during the week, the team that won this Carling Cup contest was largely made up of second-string players and beating a League Two side does not represent bouncing back in a huge way.
The Premier League champions can be backed at 17/20 (Blue Square – £25 free bets) to claim victory at Goodison Park, something that United haven’t managed to do on their last three visits to the blue half of Merseyside, with the team only managing a point at Anfield in their last away game.
After a blistering start, the Red Devils have lost their way a little and Rooney can be backed at 19/4 (Victor Chandler – £25 free betting) to open the scoring and get the team’s Premier League campaign back on track, while Javier Hernandez might be preferred to Danny Welbeck.
Everton have certainly not convinced at home this season, with their only win coming against Wigan, although David Moyes’ side came away from Fulham with a 3-1 win on Sunday which will be remembered for Bobby Zamora’s astonishing miss.
The Blues are available at 7/2 to claim victory in this north-west derby and the draw is a 13/5 chance with Louis Saha looking to get one over his former club and Everton likely to show plenty of bite where Mr Rooney is concerned.