This time, two additional El Clasico matches will take place as part of the quarter final stage to determine who will go through to the last four and both teams are struggling with injuries at the moment.
Real Madrid are top of the Spanish League by five points despite losing at home to Barca in December, with Jose Mourinho’s team having dropped just five other points all campaign. They can be backed at 9/5 (Ladbrokes – £50 free bets) to claim victory in this first leg.
There has been recent criticism of Cristiano Ronaldo’s performance in a white shirt although Mourinho was quick to defend his star player this week who still has 30 goals for the season. The former Manchester United forward is a 5/1 chance to open the scoring.
Barcelona are missing David Villa, Pedro and Ibrahim Afellay from the team, although they do seem to have the Indian Sign over their arch-rivals at the moment and many will be backing the 8/5 (William Hill – £25 free betting) that the visitors draw first blood in this cup tie.
Pep Guardiola understands the importance of these games and will select a similar team to the one that beat Real Betis on Sunday, with Barcelona tossing away a two-goal lead before rallying to win the game 4-2.
Alexis Sanchez has been among the goals in recent weeks and we are likely to see Gerard Pique and Dani Alves return to the starting line-up.