The teams have been selected by captains Davis Love III and Jose Maria Olazabal, with golf fans hoping that weather conditions are much improved on the washout at Celtic Manor which caused the 2010 renewal to be delayed.
The USA are favourites to reclaim the trophy following that narrow loss in Wales two years ago, with William Hill offering a best price 4/5 about the Americans who have a strong line-up which includes Tiger Woods.
Woods has an excellent Ryder Cup record and will be joined by the likes of Bubba Watson, Jason Dufner, Keegan Bradley and Phil Mickelson. Woods is a best price 5/1 (bet365 £200 free bets) to score the most points for his team, with Steve Stricker likely to accompany him in the four balls and foursomes.
There are four American rookies playing in Illinois and Jason Dufner is the 5/2 favourite to be the best-performing of the quartet, although Keegan Bradley and Webb Simpson are both recent major winners, while Brandt Snedeker led the 2012 Open for a long time.
As for Europe, they can be backed at 8/5 (BetVictor bookmaker) to retain their title under Olazabal and the Spaniard has been spoilt for choice when it has come to selecting his team.
Indeed, the fact that only Nicolas Colsaerts is a rookie could be an advantage for the Europeans, with the Belgian clearly meriting a wildcard place along with Ian Poulter who is a player that no American will want to take on in the singles.
Rory McIlroy, Luke Donald and Lee Westwood have all been ranked world number one and can also help the away side to claim a famous win, with Westwood competing in his 8th Ryder Cup, while Sergio Garcia is back to play in a 6th tournament and might be paired with the Englishman.
Poulter and Westwood look the best bets to be the best-performing players for their team and they can both be backed at 8/1, although McIlroy will surely also compete at every stage and he’s an 11/2 chance to justify favouritism.
For those expecting this to be a close tournament, you can get odds of 12/1 that Europe enjoy a 15-13 victory, while a 16-12 win in their favour can be backed at 14/1.
Europe only need a draw to keep the trophy and the tie is backable at 11/1, with the scores likely to be close going into the singles event on the final day.