Murray has had a wonderful tennis career to date and a Grand Slam victory is the only thing missing, especially as he has an Olympic gold medal in his locker following some striking performances at Wimbledon in July.
However, the Scot will ultimately be judged on these big matches and the 25-year-old will be hoping to make it fifth time lucky, having lost in the final of the US Open in 2008 as well as Wimbledon earlier this year and the Australian Open on two occasions.
Murray is a 2/1 chance (bet365 £200 free bets) to claim victory having recovered from a set down to beat Tomas Berdych in the semi-finals, a player who had previously defeated Roger Federer at the quarter final stage.
Indeed, Murray also lost the opening set against Marin Cilic before crushing the Croatian in four sets and he does seem to gradually improve as his matches wear on, with odds of 7/1 (Betfred bookmaker) that he claims victory in four sets at Flushing Meadows.
Even so, Djokovic will be a formidable opponent who denied Murray in the 2011 Australian Open final and the Serbian recovered from a slow start of his own against David Ferrer to ensure a comfortable passage, with the Spaniard taking just seven games from the final three sets of their match.
While the number two seed hasn’t hit the heights of 2011, he will be looking to bag a second Grand Slam success of the year, having won the Aussie Open and the match against Ferrer was the first occasion where Djokovic had dropped a set.
William Hill offer a best price 4/9 about the Serbian and the same firm go 5/2 about a straight sets win for the Djoker, although it seems likely that Murray will get at least one set and one feels that this could be an epic which means a small bet on Over 40.5 Games could be the way forward at 5/6.
Murray being a slow starter might compel backers to claim the 8/13 about Djokovic winning the first set although the Brit did enjoy a flying start to his Wimbledon final against Roger Federer before losing in four.