Williams is having a 2012 to remember after claiming victory at Wimbledon before blowing the opposition away in the Olympics and she is now a best price 5/6 (Betfred free bets) to claim a fourth US Open title, with Andrea Hlaváčková her fourth round opponent.
Even so, it’s no secret that number one seed Victoria Azarenka is a top contender and the Belarusian is cruising through her section of the draw without breaking into a sweat. Just six games have been dropped in her first three matches and perhaps the Australian Open champion has the tools to beat Williams.
Vika is a best price 11/2 (Boylesports) to claim her first title at Flushing Meadows and she gave Williams a decent match in their semi-final at Wimbledon, with Azarenka showing a clear preference for hard courts.
It’s possible that Laura Robson might meet the number one seed in the quarter final although the Brit goes into her match against reigning champion Sam Stosur as underdog, not that that has stopped her beating Kim Clijsters and Li Na in previous rounds.
However, the second quarter looks to be a competitive affair, with Maria Sharapova and Petra Kvitova on a collision course to meet in the last eight and the Russian is 7/1 (bet365 £200 free bets) to claim an overall victory.
The number three seed won the US Open six years ago but she showed her capability to win Grand Slam titles when securing the French Open earlier this year.
Perhaps another lively contender is Angelique Kerber who is the only player to have beaten Serena Williams in recent weeks and the German is a 14/1 chance to claim her first Grand Slam, having beaten Venus in an earlier round.