Defeat for Valencia in this Group E contest would mean that Los Che can no longer qualify for the Champions League group stage, something which would represent a big surprise considering they were the third-best team in Spain last season.
The Spanish side began the campaign with draws against Genk and Chelsea, although a 2-0 defeat in Leverkusen means they can ill-afford any slip-ups against their German opponents at the Mestalla, with best odds of 4/6 (Ladbrokes – £50 free bets) available about Valencia closing the gap.
Unai Emery’s side have to attack Bayer in this match, with the team unbeaten at home this term after four wins and two draws from their opening six La Liga matches. Saturday’s 3-1 triumph over Getafe was a nice way to warm up for this encounter, with midfielder Sofiane Feghouli bagging a brace and he is a 14/1 chance (bet365 – £200 free betting) to get his side off the mark.
Bayer Leverkusen know that a draw would leave them in pole position to qualify with Chelsea and the visitors are on offer at 11/4 to land a point and 5/1 to claim all three and book their place in the last sixteen.
The German side warmed up with a 1-0 win in Freiburg on Friday and their away form has actually been better than their games at home, with three victories claimed on the road this term.
Eren Derdiyok could be the man to find the net for the visitors, while former Chelsea midfielder Michael Ballack could be a key figure if Leverkusen are to stop Valencia winning this match.